Essay topic 5. Neuromuscular junction as site of disease process. AND Formation of Nuromuscular junction.

Essay topic 5. 5. The neuromuscular occasion as a post of disease process Proteins involved in shaping of the neuromuscular sum The neuromuscular junction is a severalise junction, where a push back marrow forms its synaptic terminal with a muscle grapheme, one of umteen fibres that make up a whole muscle. The mature neuromuscular junction is composed of triad types of cells - a motor kernel terminal, a muscle fibre and a Schwann cell c every last(predicate) over the junction. on the whole three of these cells argon highly differentiated and specialized for their functions (Kandel 2000, p. 1089). The events that pass off during the formation of the neuromuscular junction have been extensively canvass and are the most comprehensively understood of any nerve-to-tar set forth cell contact. Prior to formation of the synapse all three components of the neuromuscular junction develop and acquire identities independently. The muscle cells are derived from the mesode rm and reincarnate from the dermomyotomal portion of the somite. Motoneurons migrate from the ventricular zone of the neural vindication to a ventral-lateral location before axons grow out of the spinal anesthesia anaesthesia anesthesia cord. Schwann cells are glial cells, which insulate the axons outside of the spinal cord, they are derived from neural crest cells and associate with axons from the somite onwards to the peripheral device target. At the time of the first axons stretch the developing muscle, the muscle fibres are myoblasts that have just amalgamate to form multinucleated myotubes, there is no evidence to suggest that motor neurons prefer certain situate on the developing myotube or that there is a determine site for the formation of the synapse, on the contrary, synapse formation can occur on most, if not all of the myotube surface (Lichtman et al in Zigmond et al 2000, pp. 547-8). Acetylcholine receptors (AChR) are tack uniformly dispersed over the surfa ce of the... ! If you want to get a full essay, ordinate it on our website: OrderCustomPaper.com

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